Neural correlates of executive function in Alzheimer's disease and mild cognitive impairment

Objective: Executive dysfunction in Alzheimer's disease (AD) is associated with delusions, agitation and disinhibition, rapid progression and care dependency. We correlated resting cerebral glucose metabolism in Alzheimer's disease (AD) and mild cognitive impairment (MCI) with scores on the Trail Making Test (TMT) as a measure of executive function. Methods: Ten patients with AD, 10 patients with mild cognitive impairment (MCI) and 14 controls were included. We compared resting cerebral glucose metabolism in patients with that in controls and correlated TMT scores with cerebral glucose metabolism. Neuropsycholog…