Hyperlipidemia aggravates necrotizing panceatitis via altered nitric oxide synthase in rat

Background: The aim of the present study was to investigate whether hyperlipidemia can cause acute pancreatitis or alter its severity. We studied the influence of cholesterol-enriched diet-induced hyperlipidemia on the formation of pancreatic nitric oxide synthase (NOS), oxygen-derived free radicals, endogenous scavengers, heat shock proteins and nuclear factor-kappaB during acute edematous and necrotizing pancreatitis. Methods: Male Wistar rats were fed a 3% cholesterol-enriched diet or a normal diet for 16 weeks. Edematous pancreatitis was induced with 3×75µg/kg bw cholecystokinin s.c., and necrotizing pancrea…