Increased fecal serine-protease activity in patients with diarrhea-predominant irritable bowel syndrome
A Rosztóczy, R Róka, F Izbéki, T Molnár, F Nagy, J Lonovics, R Garcia-Villar, J Fioramonti, L Bueno, T Wittmann · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
The pathogenesis of irritable bowel syndrome (IBS) remains only partially understood, and no specific or universally effective patient management procedure has been developed so far. Activation of receptors for proteases located on colonocytes may participate in mucosal immune stimulation. Consequently, our study was designed to evaluate if colonic luminal serine-proteases may be altered in IBS. Methods: Fecal serine-protease (FSP), pancreatic elastase-1, mast cell tryptase, secretory leukocyte protease inhibitor (SLPI) activity was determined in 38 IBS patients (IBS-D:17; IBS-C:14; IBS-A:7), 15 patients with ul…
