Can Helicobacter pylori loose its clarithromycin resistance?

Introduction: The most effective antibiotic is Clarithromycin (CLA) in the eradication of Helicobacter pylori (Hp). In cases of unsuccessful eradication, mutation of bacterial rRNA can be detected, which evolves spontaneously giving a selective advantage for the bacteria in cases when unsuitable dose of CLA is administered. Outcome of resistance might be 1, further administration of any antibiotic will eventually eradicate bacteria 2, there is no eradication at all 3, following CLA administration resistant strain turns to sensitive (conversion). In vitro experiments revealed that the mutant strain is less viable…