Prognostic factors in colorectal cancer patients treated with first line oxaliplatin/5-fluorouracil combination

Aim: We analysed the different variables, which may potentially influence the median survival of advanced CRC patients. Methods: 42 advanced CRC patients were treated in first line setting according to Folfox4 regimen (85mg/m2 oxaliplatin on Day1, 200mg/m2 leucovorin bolus, 400mg/m2 5-fluorouracil bolus, 600mg/m2 5-fluorouracil as 22 hour continuos infusion on Day1–2) at our department between January 2003 and November 2003. All patients received second line irinotecan containing treatment. The analysed factors at the initiation of treatment were haematological parameters (WBC, RBC, PLT), CEA and ALP level, and…