Haplotypes in the insulin-degrading enzyme gene are associated with enhanced insulin clearance in non-diabetic subjects
O Pivovarova, M Osterhoff, M Möhlig, J Spranger, P Slominski, S Limborsky, AFH Pfeiffer, N Rudovich · Diabetologie und Stoffwechsel · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Aims: Insulin-degrading enzyme (IDE) is the major enzyme responsible for insulin proteolysis and is encoded by the IDE gene, which is located on chromosome 10q23-q24 within a region linked to T2DM. The aim of this study was to investigate whether genetic variants of the IDE-gene play a role in the regulation of insulin clearance in humans. Methods: We screened 10 SNP's in the IDE gene and determined their association with insulin clearance and fasting-/postprandial insulinemia in a German Caucasian population. A total of 338 subjects (age 25 to 84yrs) participated in the study. Insulin clearance was calculated a…
