Aerosolized interleukin antagonists: Potential role in the prevention of bronchopulmonary dysplasia?
M Chada, S Nögel, K von der Hardt, A Cubra, T Papadopoulos, W Rascher, M Kandler · Zeitschrift für Geburtshilfe und Neonatologie · 2006 · Heft 11
Bibliografische Angaben
Zusammenfassung
Objective: In respiratory distress syndrome (RDS), interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) are involved in the pulmonary inflammatory reaction and may play a key role in the development of bronchopulmonary dysplasia (BPD) in infants. Among inflammatory mediators IL-1 plays a role in the development of pulmonary hypertension. The purpose of this study was to determine whether pro-inflammatory pulmonary processes in surfactant depleted piglets can be successfully suppressed by systemic and aerosolized administration of an IL-1 receptor antagonist (IL-1Ra) and whether the administration of IL- 1Ra a…
