18F-FLT and 18F-FDG PET To measure response to treatment in a colorectal xenograft model

Introduction: A major issue in biological targeting is predicting response early so as to be able to modify treatment. A non-invasive method such as PET scanning may have the potential to achieve this aim. The aim of this study is to determine if PET scanning can be used to measure response to radiation with or without the COX-2 inhibitor celecoxib (Celebrex®) in a colorectal xenograft model. Material and Methods: For the development of the xenograft model, a colorectal cell line (HCT116) was injected subcutaneously in both flanks of nude mice. The mice were treated for 7 days with a dose of 5mg/kg celecoxib twi…