Integration of metabolic imaging and molecular genetic profiling of serial stereotactic biopsies are valuable for histological discrimination of oligodendrogliomas, mixed oligoast…

Introduction: Modern treatment strategies of gliomas have to consider metabolic imaging and molecular markers with respect to individualized multimodal therapeutic regimes. Aim of this study was to correlate 18F-FET-PET based tumor grading, LOH1p/19q and MGMT promoter methylation with histological classification of gliomas WHO° II/III from serial stereotatic biopsies in patients with eloquently located tumors. Method: 86 patients have been included in this prospective, single-center study. Dynamic 18F-FET PET studies have been matched with MRI scans prior to stereotactic surgery to mark regions of interest. Olig…