Inhibition of cyclin-dependent kinases by roscovitine induces suppression of proliferation and migration in human glioma cells

Introduction: Cyclin-dependent kinases (CDK) play an important role in numerous cellular processes. CDK1, 2, 3, 4 and 6 are potent regulators of the cell cycle machinery, whereas CDK5 activity is limited to the CNS as a key regulator of neural development and neuronal cytoarchitecture. Galectins are overexpressed in different types of neoplasms and are also involved in various cellular processes, including resistance to apoptosis, proliferation and migration. Roscovitine is an orally available small-molecule inhibitor mainly of CDK5, and with lower activity of CDK-1, -2, -7 and -9. Davanat is a polysaccharide-ga…