COX–2 is overesxpressed in ovarian endometriosis and might represent a therapeutic target

Aims: Recent studies have suggested that cyclooxygenase–2 (COX–2) is involved in the pathogenesis of endometriosis. The aim of this study was to investigate the expression of COX–2 in different anatomical sites of endometriosis Methods: COX–2 expression was analysed immunohistochemically in 60 samples of endometriotic tissue from different anatomical sites (25 ovarian, 14 uterine, 21 peritoneal/Fallopian tube/omental endometriosis) using a monoclonal antibody against COX–2. Staining results were analysed semiqiantitatively for staining intensity and percent of positive cells. Results: COX–2 immunoreaction was ob…