Fibronectin testing combined with cervical length assessment estimating the risk of birth before 35 weeks in high risk patients – A retrospective study

Introduction: Preterm birth (PB) is the leading cause of neonatal mortality and morbidity in the industrialized world. However, the identification of women at risk for PB remains a challenge. Sonographic assessment of cervical length (CL) has been the gold standard in estimating the risk of PB. Currently, fetal fibronectin (fFN) has become an additional instrument. Objective: To determine whether two-step testing (CL plus fFN) increases overall specificity, sensitivity, positive and negative predictive values and whether women with a high risk for PB assessed by CL measurement, but with a negative fFN are actual…