A Polymorphism in the CASP10 Gene is associated with survival in ovarian cancer patients
FC Thiel, P Strissel, R Strick, K Beckmann, M Schrauder, MW Beckmann, PA Fasching · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Single Nucleotide Polymorphisms (SNPs) are proven to have an influence in cancer susceptibility and prognosis of several cancers. Aim of our study was to analyze six SNPs with regard to survival in a group of ovarian cancer (OC) patients. Patients and methods: 121 patients with primary OC were included in our analysis. All patients were recruited to our study prospectively. Six SNPs were analyzed. Genes included are ESR, PGR, ERCC, CASP10, CYP19 and TNF-alpha. Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier-Curves and log-rank-test. Results: ESR, ERCC, CYP19 a…
