Analysis of a single nucleotide polymorphism in the promoter region of estrogen receptor beta gene in women with breast cancer

Objective. Estrogens are involved in both normal mammary development and in breast carcinogenesis. A family history of disease and exposure to estrogens are major risk factors for developing breast cancer. Genetic variations like single nucleotide polymorphisms (SNPs) in genes involved in estrogen biosynthesis, metabolism and signal transduction have been suggested to play a role in breast cancer risk. In this study we tested the hypothesis that polymorphisms in the promoter region of estrogen receptor beta (ESR2) gene may be associated with increased risk for breast cancer. Methods. We tested three ESR2 promote…