Ligand-Mediated Selective Targeting of Adenovirus in Metastatic Breast Cancer – Bispecific Adaptor for Breast Cancer Virotherapy
S Bhatia, S Bhatia, Y Odaka, AA Rivera, RK Schmutzler, JM Mathis, MA Stoff-Khalili · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Ligand-Mediated Selective Targeting of Adenovirus in Metastatic Breast Cancer Introduction: The success of gene therapy relies on efficient and targeted delivery systems. Adenovirus vectors have a number of advantages for gene therapy. However, one main problem is their lack of tumor tropism. Many solid tumors and hematopoietic tumors over express the chemokine receptor CXCR4. Recent evidence has highlighted the role of CXCR4 in cancer, particularly in cancer metastasis. The present study addresses this issue by retargeting adenovirus to the breast cancer cells overexpressing CXCR4 receptor. We used sCAR-T4-CXCL…
