Differences in the antiviral properties of the novel IL-10 like cytokines IL-26, IL-28A/B, and IL-29 against hepatitis C virus infection
J Diegelmann, F Beigel, K Zitzmann, A Kaul, B Göke, CJ Auernhammer, R Bartenschlager, H Diepolder, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background/Aim: The novel IL-10 like cytokines IL-22, IL-26, IL-28A/B, and IL-29 share the IL-10R2 receptor subunit for signaling. Antiviral activity of IL-28A/B and IL-29, also known as IFN-λs, has been previously described, while we recently demonstrated no therapeutically relevant effect of IL-22 against hepatitis C virus (HCV) infection. In contrast, the potential functions of the IFN-λ-related cytokine IL-26 in viral disease are unknown so far, which we therefore analyzed in hepatic cells. Methods: Induction of the antiviral proteins MxA and 2',5'-OAS in hepatic cells was analyzed by luciferase assays. Hepa…
