Patients with celiac sprue have an increased incidence of white matter brain lesions on cerebral magnetic resonance imaging (MRI)

Aims: Celiac sprue causes neurological symptoms in 10% of patients. Clinical presentation can be subtle and may even occur in the absence of gastrointestinal symptoms. Common neurological manifestations of celiac disease include ataxia and polyneuropathy. White matter lesions (WML) occur in a variety of inflammatory conditions and can be detected with cerebral magnetic resonance imaging (cMRI). Their prevalence in patients with elevated gliadin serum antibody levels or celiac sprue is not known. Methods: In this prospective, comparison study 41 adult patients with either WML of unknown etiology (group 1) despite…