Association of TNF-a gene polymorphisms with the occurrence of uterine leiomyoma

Tumor necrosis factor alpha (TNF-alpha) is an important regulator concerning immunology and inflammation. Furthermore, it is controlling angiogenesis as well as apoptosis. Disturbance of these processes are one of the most important requirements for the development and growth of malign or benign tumors, such as uterine leiomyoma. In humans, variant alleles of TNF-alpha are associated with altered RNA and serum protein levels. This study investigated the association between the occurrence of uterine leiomyoma and two SNPs of the TNF-alpha-308 and TNF-alpha-863 genes. Genotyping was performed by polymerase chain r…