CareLit Fachartikel

Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo

K Hancke, C Kissel, H Göbel, E Stickeler, W Schäfer, G Gitsch, D Denschlag · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09

Dokument
1011475
CareLit-ID
Jahr
2006
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
K Hancke, C Kissel, H Göbel, E Stickeler, W Schäfer, G Gitsch, D Denschlag
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-19 00:00:00
ISSN
0016-5751
DOI
10.1055/s-2006-952554

Zusammenfassung

Objective: To investigate whether sphingosine-1-phosphate (S1P), an apoptosis-inhibitor would be able to protect ovarian follicles from chemotherapy-inducedcell death in-vivo. Interventions: Twenty mice were randomly assigned into three groups: in group A (n=8) each mouse received an injection of low concentration of S1P (A1: 0.5 mM), prepared in a vehicle (PET) into the bursa of one ovary and a high concentration (A2: 2.0 mM S1P) to the contralateral ovary. In group B (n=8), only PET was injected to both ovaries. Afterwards, both groups received 100µg Dacarbazine i.v. The control group C (n=4) received no chemo…

Schlagworte

Geburtshilfe und Frauenheilkunde