Grip-force variability in asymptomatic carriers of the Huntington gene – a biomarker for presymptomatic clinical studies?
R. Reilmann, S. Bohlen, F. Kirsten, H. Lohmann, D. Bracht, R. Bachmann, M. Weckesser, H.W. Lange, E.B. Ringelstein · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Isometric grip force variability (GFV) in Huntington's Disease (HD) was shown to correlate with (1) the severity of motor deficits in HD as assessed in the UHDRS (Gordon et al. 2000), (2) the CAG-repeat length when normalized for age (Reilmann et al. 2004), and (3) the degree of atrophy observed in the caudate nucleus on MRI volumetry (Reilmann et al 2005). Furthermore grip force variability was shown to increase in the course of HD (Reilmann et al. 2001). Objective: To investigate whether GFV in a grasping and holding task is pathologically increased in clinically asymptomatic carriers of the Huntington g…
