Modified somatosensory processing in PINK1 (PARK6)-mutation carriers: preclinical evidence by the use of quantitative sensory testing

Introduction: Sensory symptoms are common in Parkinson's disease (PD). It is unclear whether these symptoms are of primary origin or secondary due to pathophysiological changes occurring in PD. Recently, mutations of the PINK1 (PARK6) gene have been identified as one cause for the development of PD. Asymptomatic carriers of PINK1 mutations represent individuals at risk who can be identified prior to the development of PD by molecular genetic testing. Therefore, PINK1-associated PD may serve as a model to detect presymptomatic signs and sensory abnormalities before subjects show definite clinical signs of PD. Thi…