CareLit Fachartikel
Lipocalin-2 (LCN2) expression during transdifferentiation of rat hepatic stellate cells and its potential impact on liver fibrogenesis
F Drews, E Borkham-Kamphorst, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2009 · Heft 01
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1011789
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Jahr
2009
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Zusammenfassung
Background and aims: The lipocalin protein family contains a group of small secreted extracellular proteins with the ability to bind small hydrophobic molecules. They are involved in the regulation of the immune response and cell homeostasis. Lipocalin-2 (LCN2), also known as Neutrophil gelatinase-associated lipocalin (NGAL), is an inflammatory marker abundantly expressed in adipose tissue and liver and induced by oxidative stress [1, 2]. Additionally, we have previously shown that the expression of LCN2 is TGF-β1-dependent in hepatic stellate cells (HSC) [3]. Methods: HSC were isolated from Sprague-Dawley rats…
Schlagworte
LCN2
Lipocalin
fibrogenesis
marker
transdifferentiation
Zeitschrift für Gastroenterologie
