The neuronal guidance cue and survival factor, Netrin-1, in liver fibrogenesis
D Lopez, F Schulze, M Scheffler, S Mesghenna, K Wendland, U Töx, U Drebber, D Nierhoff, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Netrin-1 has been discovered as a guidance cue for commissural axons via its receptor DCC (deleted in colorectal cancer) und the UNC5H receptor family. The netrin-1 receptors including UNC5H have been shown to be dependence receptors which induce apoptosis when devoid of their ligand. Accordingly, netrin-1 serves as a survival factor for different cell types. In the present study we investigated the expression of netrin-1 and its receptor UNC5H2 in the rat liver and its possible impact on fibrogenesis. Methods: Hepatic stellate cells (HSC) were isolated from rats and taken in primary culture. Pattern of ge…
