CareLit Fachartikel
Activation of the lipogenic phenotype predicts poor prognosis in human hepatocellular carcinoma
DF Calvisi, M Evert, F Dombrowski · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1011794
CareLit-ID
Jahr
2009
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Emerging evidence indicates that lipogenic enzymes are induced in hepatocarcinogenesis, but their role liver cancer development and progression remains poorly delineated. In the present investigation, we determined the levels and biologic role of the main lipogenic enzymes in a human hepatocellular carcinoma (HCC) collection. Levels of Fatty Acid Synthase (FASN), Acetyl-CoA Carboxylase (ACACA), ATP citrate lyase (ACLY), and Steroyl-CoA Desaturase (SCD) were all upregulated in HCC compared with corresponding noncancerous livers. Of note, the highest expression of lipogenic enzymes occurred in tumors with poor pro…
Schlagworte
Lipogenic phenotype
Fatty Acid Synthase
hepatocellular carcinoma
liver tumor treatment
isopeptidase ubiquitin-specific protease-2a
Zeitschrift für Gastroenterologie
