FBP-1 induces protumorigenic effects through EGR-1-dependent autocrine stimulation of IGF-II in liver cancer cells

F ar upstream sequence element (FUSE) binding proteins (FBPs) represent a novel group of factors that induce proliferation and migration in HCC cells. FBP-1 is a multifunctional factor that has been ascribed to various mRNA processing functions such as transcription, splicing, mRNA stabilization, and transcript degradation. However, the underlying molecular mechanisms of FBP-1-dependent effects in human carcinogenesis are largely unknown. In an attempt to identify the relevant downstream effectors of FBP-1 overexpression in HCC cells, we performed transcriptome profiling analyses after gene-specific, siRNA-media…