CpG A ODN can activate tumorspecific lymphocytes in the orthotopic VX2 hepatoma in rabbits

Solid malignant hepatic lesion such as metastases or primary liver cancer are still an unsolved burden of gastrointestinal oncology. ODN CpG have shown a specific reactivity to certain TLR receptors on dendritic cells. Recently it was shown, that CpG A is a potent drug recruiting especially T memory cells by activation of TLR 8 and 9. The aim of this study was to show if ODN CpG A is effective in the solid VX2 hepatoma model in rabbits. Material and Methods: 12 rabbits suffering from a VX2 hepatoma were treated with ODN CpG A for 120 and were sacrificed thereafter. Blood was sampled into citrate buffer before im…