Stromal Cells Derived from Non-Small Cell Lung Cancer and Normal Lung Tissue Display Mesenchymal Stem Cell Characteristics and Differ in Their Gene Expression Profiles and Functio…
S Gottschling, A Jauch, M Granzow, R Kuner, T Muley, H Hoffmann, H Dienemann, V Eckstein, AD Ho, FJF Herth, M Thomas, M Meister · Pneumologie · 2009 · Heft 03
Bibliografische Angaben
Zusammenfassung
Stromal microenvironment plays a vital role for the induction and maintenance of solid tumours. However, detailed knowledge on the microenvironment in non-small cell lung cancer (NSCLC) is scanty. Here, we provide a systematic and comparative analysis of genetic and functional properties of autologous stromal cells (SC) derived from NSCLC and microscopically normal lung tissue (NLT) of five newly diagnosed lung cancer patients. SC were derived from 2 large cell, 2 squamous cell, and 1 adenocarcinoma. For all analyses, SC of passage 5 were used. Screening by comparative genetic hybridization revealed no genetic a…
