Funktionelle Untersuchungen von Ionenkanälen in unmyelinisierten Axonen des Menschen

Clinical assessment of large fibre neuropathy is a routine neurological procedure. The clinical assessment of small fibre function however is far less well established and as a consequence pharmaceutical therapies for small fibre neuropathies often comprise sequential trials with different medications until one works. To refine the diagnosis and treatment of small fibre neuropathies a fuller understanding of the physiological and pharmacological profile of human unmyelinated axons is required. To this end we have adopted the in vitro preparation of human sural nerve segments first described by Lambert and Dyck (…