The rate of progression to type 1 diabetes in children at high genetic risk has increased since 1989

Background: Type 1 Diabetes (T1D) is one of the most common chronic diseases in childhood. The etiology of T1D remains unknown, and the incidence is increasing by 3–5% per year, particularly in young children. In Germany, children with increased risk for T1D are continuously recruited from birth into 'prospective natural history cohort studies' since 1989. We here compared the rate of progression to T1D over time since 1989 until today in children participating in the BABYDIAB study and in the TEDDY study, using TEDDY HLA eligibility criteria. Methods: The BABYDIAB study follows 1650 offspring of mothers or fath…