Neuronal functions, feeding behavior and energy balance in Slc2a3+/- mice
S Schmidt, M Richter, V Gawlik, D Montag, T Sartorius, R Augustin, R Kluge, P Ruth, HG Joost, A Schürmann · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Glucose is the primary source of energy for the mammalian brain. The transport of glucose into neuronal cells is predominantly mediated by the glucose transporter GLUT3, a member of the GLUT-family of facilitative glucose transporters. This family comprises 14 members, GLUT1–12, GLUT14 and HMIT1 (H+/myo-inositol symporter), that differ in their tissue distribution, substrate specificity and kinetics of transport. GLUT3 exhibits a high affinity to glucose (Km=1.8 mM) and shows major expression in brain, testis and during embryogenesis. However, its physiological relevance is still unknown. Material &…
