Vascular mimicry and neo-angiogenesis of Ewing Tumors explored based on the identification of angiogenetic target structures

Aims: Metastatic spread in Ewing Tumors (ET) is hematogenous and malignant features have been shown to correlate with hypoxia and angiogenesis. We confirmed the endothelial signature by microarray analysis. This analysis revealed 37 genes that are highly up-regulated or even specifically expressed in ET including genes that may play a central role in angiogenesis of this tumor: Chondromodulin-1 (CHM1), a cartilage glycoprotein with anti-angiogenic activity, is believed to be involved in vasculogenic mimicry of tumor cells. G-protein coupled receptor-64 (GPR64) is an orphan receptor with normal expression restric…