Serum matrix metalloproteinase -2, -7 and -9 in the normal mucosa-adenoma-colorectal carcinoma sequence
L Herszényi, I Hritz, G István, F Sipos, G Lakatos, I Pregun, Z Elekes, M Juhász, Z Tulassay · Zeitschrift für Gastroenterologie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Matrix metalloproteinases (MMP-s) play a part in colorectal cancer (CRC) invasion and metastasis. Strong expression of many MMPs has been related to poor survival in CRC patients. However, the behavior of serum MMPs has scarcely been investigated in the normal mucosa-adenoma-adenocarcinoma sequence of the colon. Methods: The MMP-2, MMP-7 and MMP-9 serum levels were determined in 14 patients with CRC, 8 patients with colorectal tubulovillous adenoma and low-grade dysplasia, 10 patients with inflammatory bowel disease (IBD) and 8 tumor-free control patients by ELISA technique. Statistical analysis with…
