Impaired cognitive function in Hepatitis C infected patients correlates to regional reductions of resting glucose metabolism

Question: Among patients with chronic hepatitis C virus (HCV) infection liver cirrhosis is rarely observed whereas extrahepatic manifestations such as fatigue and neurological symptoms occur in about 50%. Aim of the study was to look for alterations of cerebral glucose metabolism in HCV infected patients with only mild if any liver disease and its correlations to cognitive dysfunction and fatigue. Methods: Nineteen female patients (51±7 years) who had been infected with HCV via immunoglobulines for Anti-D-prophylaxis in 1978/79 completed depression, fatigue and quality of life questionnaires, psychometric tests…