Finger tapping as an objective motor phenotype marker in pre-manifest and symptomatic Huntington's disease – cross-sectional results from the TRACK-HD Study
N Bechtel, C Jauffret, M Say, A Sturrock, S van den Bogaard, JA Mills, TP Archarya, DR Langbehn, H Johnson, B Borowsky, A Durr, B Leavitt, R Roos, JC Stout, SJ Tabrizi, B Landwehrmeyer, R Reilmann · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aims: Currently, the Unified Huntington's Disease Rating Scale (UHDRS) is the gold standard of motor assessment in Huntington's Disease (HD). However, the UHDRS is limited by inter-rater variability and low sensitivity, particularly in early stages of HD. Therefore, objective and quantitative measures of motor phenotype are of interest. Various tapping techniques have detected motor deficits, even in pre-manifest subjects (Paulsen et al. 2008). We developed a force transducer-based assessment for tapping that provides innovative measures. Objective: To investigate whether these measures provide sensitive, object…
