Biological IFNβ s.c. treatment response networks derived from whole genome RNA profiles of MS patients

Objective: This longitudinal systematic gene expression study focuses on MS and the effects of medication by subcutaneous Interferon-β-1b (IFNβ1b). It is the aim to attain human peripheral blood derived gene transcripts that are differenzially regulated throughout therapy and to infer accessory regulatory pathways of the applied drug. Method: Employing the Affymetrix HGU133A/B array (45.000 transcript species), a full genome study was performed monitoring 25 RRMS patients that received IFNβ1b (s.c.) over a period of 2 years. Peripheral blood mononuclear cells were collected before first treatment and correspondi…