Introduction of a novel strategy in virotherapy for breast cancer
MA Stoff-Khalili, S Brüggemann, U Sandaradura de Silva, DT Curiel, M Warm, P Mallmann, MJ Mathis · Geburtshilfe und Frauenheilkunde · 2009 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: In view of the limited success of available treatment modalities for a wide array of cancer such as metastatic breast cancer, alternative and complementary therapeutic strategies need to be developed. Virotherapy employing conditionally replicative adenoviruses (CRAds) based on the adenovirus serotyp 5 (Ad5) represents a promising targeted intervention relevant to a wide array of neoplastic diseases. Critical to the realization of an acceptable therapeutic index using virotherapy in clinical trials is the achievement of oncolytic replication in tumor cells, while avoiding non-specific replication in…
