Major histocompatibility complex class I chain-related molecules A and B (MIC A/B): A role in the pathogenesis of non-alcoholic steatohepatitis
A Kahraman, P Kocabayoglu, S Yildiz-Meziletoglu, A Kilicarslan, J Erhardt, CD Fingas, HA Baba, G Gerken, A Canbay · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and aims: Hepatocellular apoptosis is a key mechanism of liver injury in the pathogenesis of non-alcoholic steatohepatitis (NASH). Recently, soluble forms of major histocompatibility complex (MHC) class I-related chains A and B (MIC A/B) were reported to be increased in the sera of patients with chronic liver disease and hepatocellular malignancy. However, the role of MIC A and B in the pathogenesis of NASH has not been explored. We thus aimed to investigate the impact of these stress-induced ligands on liver injury, apoptosis and hepatic fibrosis in patients with NASH. Methods: Blood and liver tissue…
