TGF-b drives hepatic progenitor cell activation during liver damage
H Weng, L Ciuclan, Y Liu, E Wiercinska, T Huang, J Li, C Meyer, R Gebhardt, R Heuchel, P Ten Dijke, MV Singer, PR Mertens, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Einleitung: Hepatic progenitor cells (HPCs) instead of normal hepatocytes represent a major source of regenerative hepatocytes, promote a periportal ductular reaction (DR), which contributes to periportal fibrogenesis in chronic liver disease. Ziele: We hypothesized that a TGF-b-dependent activation of HPCs and a DR are critical in chronic HBV-associated fibrogenesis and cirrhosis. Methodik: 105 biopsied liver tissues with chronic HBV infection were stained with cytokeratin-7 (CK7) to quantify HPC activation and DR, and with p21 to assess hepatocyte replication arrest. Ergebnisse: CK7 showed a significant correl…
