Dual selective antitumor effect of 5-azacytidine towards hepatocellular carcinoma cells
S Venturelli, A Berger, T Weiland, M Zimmermann, I Smirnow, TS Weiss, A Königsrainer, M Gregor, UM Lauer, M Bitzer · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction/aim: Epigenetic alterations play a major role during the development and maintenance of hepatocellular carcinoma (HCC) and a wide variety of other tumor entities. 5-azacytidine (5-aza-CR) and 5-aza-2'-deoxycytidine (5-aza-dC) are the most advanced drugs for a demethylating epigenetic therapy. Due to HCC resistance phenomena to chemotherapeutics or antitumor cytokines, such as the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), great efforts are made to unravel new antitumor therapies. Methods: Human-derived primary hepatocytes (PHH), primary human-derived liver slices from different…
