Excluding Maternal Background Risk in First Trimester Screening – Analysis of a Novel Test Strategy

Objective: As a defined basic risk, the maternal background risk represents the most important influencing factor in the First Trimester Screening (FTS) according to Nicolaides [1–4]. However, the generated risk estimations often deviate from the observed clinical-practical values [5]. The aims of this study were a test performance analysis of the FTS according to Nicolaides and its comparison with the novel "Advanced First Trimester Screening (AFS) ®" algorithm, which explicitly excludes the maternal background risk [5]. Material and methods: At the medical university of Hanover 2,743 pregnancies at 11+0 to 13+…