TGF-β interference with MEOS and ADH metabolising systems may promote alcohol dependent liver damage

Aims: Fibrogenesis involves cytokines, acetaldehyde, oxidative stress and complex interactions between liver cells. Hepatotoxic effects of chronic alcohol comsumption result from activating ADH and MEOS systems. TGF-β is induced in liver of patients with alcoholic liver disease, suggesting its involvement adverse effects of alcohol, however, a molecular connection was not yet identified. Aim: To show a crosstalk between TGF-β signaling and alcohol dependent damage in hepatocytes. Methods: Using DNA microarrays, a TGF-β dependent expression profile was established for hepatocytes. Results were confirmed by RT-PCR…