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Antigen-presenting function of rat hepatic stellate cells

M Bomble, G Hegasy, F Winau, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1013197
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Bomble, G Hegasy, F Winau, AM Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967864

Zusammenfassung

Introduction: Human and mice hepatic stellate cells (HSCs) are professional antigen-presenting cells (APCs) because they express factors such as MHC-II and co-stimulatory molecules on their surface. They can enhance homeostatic proliferation of natural killer-T cells localized in the liver through the expression of Interleukin–15 (IL–15). Recently, it was demonstrated that HSCs present peptides to CD8+ and CD4+ T cells and mediate cross-priming of CD8+ T cells [Winau et al., submitted]. Aim: The present study aims to analyse the regulation and expression pattern of the surface molecules MHC-I, MHC-II, and CD1d d…

Schlagworte

MHC-I MHC-II antigen-presenting cells hepatic stellate cells interleukin Zeitschrift für Gastroenterologie