CareLit Fachartikel
G–300A interferon regulatory factor-1 promoter polymorphism is associated with the outcome of hepatitis C virus infection
A Maouzi, P Wietzke-Braun, LB Mänhardt, H Bickeböller, G Ramadori, S Mihm · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
1013198
CareLit-ID
Jahr
2007
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Zusammenfassung
Background and Objectives: Interferon-α (IFN-α) is an important mediator for the host's innate antiviral defense system that also is used for the treatment of persistent viral infections. The aim of this study was to investigate whether two functional polymorphisms in genes which are involved in IFN-α signal transduction and effector function are associated with (i) the natural outcome of hepatitis C virus (HCV) infection and (ii) the responsiveness of chronic hepatitis C patients to IFN-α therapy. Methods: Forty-four individuals who had resolved HCV infection spontaneously and 147 patients who developed chronic…
Schlagworte
HCV
anti-HCV
hepatitis C
persistent infection
self-limited infection
Zeitschrift für Gastroenterologie
