RAGE-dependent glyoxalase-1 impairment mediates functional deficits in diabetic neuropathy

Introduction: Glycation of proteins, nucleotides and phospholipids contributes to the development of late diabetic complications at least in part via interaction with their cellular receptor RAGE. Reactive intermediates of AGE formation such as glyoxal, methylglyoxal (MG) and other dicarbonyl compounds are detoxified by the glyoxalase-system. Since RAGE-/– mice are partly protected from late diabetic complications including diabetic neuropathy (DN), we studied the expression of the AGE-detoxifying enzyme glyoxalase-1 (GO1) in peripheral nerves and dorsal root ganglia (DRG) of healthy and diabetic wildtype (WT)-…