Diagnostic gene expression signatures to predict the chemotherapy resistance against oral and intravenous 5-fluorouracil

Colon cancer is the second most common malignant disease in Hungary. The most frequently used drug is 5-fluorouracil, which has no effect in the 90% of the cases. The main mechanisms of the resistance against 5-fluorouracil are due to the overexpression of dihydropyrimidine dehydrogenase, B p65. The investigation of these single markers κMRP8, timidilate synthetase, NF has not yet provided clinically useful results, thus the simultaneous investigation of multiple markers is needed. DNA microarrays provide the best available technology for this purpose. Based on previous publications, we have set up a consensus g…