Does growth restriction at birth contribute to the interindividual variability of renal drug clearance in the first month of life?

Background: Aminoglycosides and glycopeptides are almost exclusively eliminated by renal route. Postmenstrual age (PMA) is the best predictor of their clearance, presumably because it predicts the time course of development of the glomerular filtration rate (GFR). Intrauterine growth restriction has an impact on the normalized weight of the kidney, on the number of nephrons, on GFR and on tubular function in human perinatal life. We therefore investigated whether prenatal growth also effects clearance of drugs such as aminoglycosides or glycopeptides that are eliminated through the renal system. Methods: Observa…