RNA expression signatures in peripheral blood cells of interferon-beta 1a (IM) treated MS patients disclose differentially expressed genes of therapy predicting value

Objective: This longitudinal systematic gene expression study focused on the disease multiple sclerosis (MS) and the effects of medication by interferon-beta-1a (IFNß1a). It was the aim to detect surrogate markers for therapeutic intervention (discern RNA-profiles derived from (non-)responders to treatment) in human PBMCs and to infer accessory regulatory pathways of applied MS drug. Background: interferon-beta (IFNbeta) therapy in patients with MS has proven efficacious, but appears suboptimal in terms of therapy responder rate and adverse events. Large scale analysis of peripheral blood messenger RNA transcrip…