A mediator cocktail released from mucosal biopsies of IBS patients excites human and guinea-pig enteric neurons
S Buhner, Q Li, S Vignali, CW Hann von Weyhern, F Zeller, B Giovanni, R De Giorgio, V Stanghellini, K Michel, M Schemann · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Irritable bowel syndrome (IBS) is one of the most common reasons for referral to a gastroenterologist. Treatment remains unsatisfactory due to the poorly understood pathophysiology of IBS. IBS symptoms may be linked to altered mediator release from the gut epithelium. Aims: The aim of the present study was to investigate the effect and pharmacology of a mediator cocktail that is released into the supernatants from mucosal biopsies of 6 IBS patients (2 constipation and 4 diarrhea predominant IBS) on human and guinea-pig (GP) enteric neurons. Supernatants from biopsies which were taken from healthy v…
