Effect of STW 5 and its component STW 5-K IX in a model of intestinal inflammation in vitro

The phytomedicine STW 5 (Iberogast) contains nine herbal extracts. In models of gastric motility its component STW 5-K IX (greater chelandine herb) has been shown to significantly contribute to the tonicising effect of STW 5 in antral muscle. The aim of the present study was to test, whether it also contributes to the effect of STW 5 in an inflammatory model in vitro. The experiments were performed on isolated ileum/jejunum preparations in conformity with the German Guidelines for Animal Care. The inflammation was induced with 2,4,6 trinitrobenzolsulfonic acid (TNBS, 0.01M). The ACh-induced (1mM) contractions we…