The role of SLC26A6 and CFTR in acid-induced and prostaglandin E2-stimulated duodenal bicarbonate secretion in vivo

Background & aims: Duodenal mucosal HCO3– secretion is a key factor in epithelial protection against injury by the acid discharged from the stomach. The aim of this investigation was to elucidate the role of the chloride/base exchanger SLC26A6, which is highly expressed in duodenal brush border membrane, and the cystic fibrosis transmembrane regulator (CFTR) in basal and stimulated murine duodenal HCO3– secretion in vivo. Methods: Basal, forskolin- and PGE2- stimulated HCO3– secretion was examined in Slc26a6- and CFTR-deficient mice and in their wild type (WT) counterparts. The isolated proximal duodenum was per…